RAD-140

where to buy rad-140, Rad140, also known as Testolone, is one of several selective androgen receptor modulators (SARMs) that was initially developed as a potential alternative to testosterone replacement therapy. It should not be confused with it’s esterified form, RAD 150, also known as TLB 150. Like all SARMs, RAD140 binds to the androgen receptors (AR) in a selective manner and does not produce the full range of androgenic effects as similar substances like testosterone, DHT, or anabolic steroids. RAD140 demonstrated excellent affinity for the AR (Ki = 7 nM), higher even than DHT and most anabolic steroids [1]. For reference, the the affinity for the androgen receptor (AR) for Testosterone in this preclinical model was 29 nM, and 10 nM for DHT. Unlike testosterone and most other AR mediated anabolic agents, Testolone is orally bioavailable so it does not require injection for proper absorption and it is considered by many researchers to be one of the best SARMs for bulking and adding lean body mass.where to buy rad-140, rad-140

Testolone is a fairly recent addition to the list of SARMs for sale; it was developed in 2010 as a possible treatment for osteoporosis and muscle gains. More recent testing performed on rats and primates as well as a human clinical trial have indicated that it may provide additional benefits as well.where to buy rad-140, rad-140

RAD 140 Mechanism of Action

In Vitro, the RAD140 SARM has produced a wide array of effects including:

• Increased weight loss and body fat loss
• Increased lean muscle growth and protein synthesis
• Increased removal of beta amyloid plaques from the brain [2]
• Increased protection against breast and prostate cancer
• Increased endurance

Studies including RAD 140

However, it must be understood that the Food and Drug Administration (FDA) has not confirmed any health effects of RAD 140 for human beings or approved it for human use, and the drug should be used for laboratory research use only. Anecdotal reports indicate a potential for testosterone suppression and other side effects in males from RAD 140 administration. There have been a number of studies performed on animals, such aswhere to buy rad-140, rad-140 for sale

• One study on rats found that RAD140 had neuroprotective benefits of a kind that may prevent Alzheimer’s disease and similar disorders, and may be safer than conventional testosterone therapy [3]. The group treated with 3 mg/kg RAD140 was able to replicate the same level of muscle tissue growth as the group treated with 1 mg/kg Testosterone, with about half of the androgenic activity in the prostate.where to buy rad-140
• RAD-140 has shown neuroprotective effects in another rat study by activating androgen receptors in the brain, protecting hippocampal neurons from cell death and reducing beta-amyloid plaque formation [2].
• Another study, performed this time on primates, indicated that RAD140 may promote increases in lean muscle mass and muscle gains .
• Androgen therapy has widely been considered in the fight against breast cancer but due to the side effects of anabolic steroids, SARMs like RAD-140 are being considered at this time. In a preclinical study RAD140 significantly suppressed the growth and proliferation of cancer cells in in vivo and in vitro models of AR/ER+ breast cancer .where to buy rad-140

Side effects of RAD 140

While RAD140 and other SARMs do not cause androgenic side effects to the same extent as anabolic steroids like Testosterone, anecdotal reports have revealed the potential for nausea, aggression, or mild male pattern hair loss from the use of RAD 140. A single-member case report indicated drug-induced liver injury after 11 months of the use of an anti-depressant, as well as intermittent use of RAD 140 and LGD-4033. The limitations of this study however are the fact that it includes only one test subject, 11 months of concurrent antidepressant use, the quality and dosage of SARMs used by the subject were not monitored, and that additional comorbidities were not investigated [7]. Several case reports exist indicating the potential for selective androgen receptor modulators to contribute to liver injury but none involve a significant sample size or test controls to date. Like other SARMs, RAD 140 may trigger a negative feedback loop and a reduction in natural testosterone production and testicle size though further research is needed to determine the likelihood and severity of this occurrence.where to buy rad-140